Current Appointments:

Current Business Contact Information:
Address: The Russell H. Morgan Department of Radiology and Radiological Science
601 N. Caroline Street, JHOC 4263
Baltimore, MD 21287-0859
Phone: (443) 287-4025
Fax: (410) 614-1977

Education and Training:

Professional Experience:

ADMINISTRATIVE APPOINTMENTS

Director, Division of Medical Imaging Physics, The Russell H. Morgan Department of Radiology, Johns Hopkins University, July 2002 – present

The responsibilies include directing and administrating the Dvision of Medical Medical Imaging Physics including directing the scientific activities and managing research grants and contracts from the NIH, private foundation and industry. The time commitment is 5%.

Interim Chair, Department of Biomedical Engineering (BME), UNC-CH, November 2001 – June 2002

The responsiblities are the same as the Chair of the Department of BME during the search for the next Chair of the Department. The time commitment is 10%.

Vice Chair, Department of Biomedical Engineering (BME), UNC-CH, January 1999 - October 2001

The responsiblities include consulting and advising the Chair in regard to departmental administration matters and to stand in for the Chair in her absence. The time commitment is 2%.

Director of Research and Chair, Research Committee, Department of BME, UNC-CH, 1991 – October 2001

The responsiblities include encouraging and coordinating research activities, acting as the Chair of the Research Committee, and organizing the yearly Department Research Review. The time commitment is 3%. 

Director, Imaging Track, Department of BME, UNC-CH, 1989-2002

The responsibilies include directing and coordinateing the research and teaching activities in medical and small animal imaging. The time commitment is 5%.

Director, Medical Imaging Research Laboratory, Department of BME, UNC-CH, 1988-2002

The responsibilies include directing and managing research grants and contracts from the NIH, private foundation and industry. The time commitment is 10%.

RESEARCH ACTIVITIES

Publications
 

.     Chuang LS, and Tsui BMW.  Fabrication and Characteristics Study of a Surface Barrier Silicon Solid-State Particle Detector.  Am J Phys 40:1679-1683, 1974

2.   Metz CE, Tsui BMW, and Beck RN.  Theoretical Prediction of the Geometric Transfer Function for Focused Collimators.  J Nucl Med 15:1078-1083, 1974

3.   Tsui BMW, Beck RN, Metz CE, Atkins FB, and Starr SJ.  A Comparison of Optimum Detector Spatial Resolution in Nuclear Imaging Based on Statistical Theory and on Observer performance.  Phys Med Biol 23:654-675, 1978

4.   Tsui BMW.  A Correction to a Comparison of Optimum Detector Spatial Resolution in Nuclear Imaging Based on Statistical Theory and Observer Performance.  Phys Med Biol 23:1203, 1978

5.   Atkins HL, Robertson JS, Croft BY, Tsui BMW, Suskind H, Ellis KH, Loken MK, and Treves S.  Estimates of Radiation Absorbed Doses from Radioxenons in Lung Imaging.  J Nucl Med 21:459-465, 1980

6.   Tsui BMW, Beck RN, Metz CE, and Doi K.  Transfer Function Analysis of the Total Image Forming Process in Nuclear Medicine.  J Appl Photo Eng 6:131-140, 1980

7.   Tsui BMW, Beck RN, Doi K, and Metz CE.  Analysis of Recorded Image Noise in Nuclear Medicine.  Phys Med Biol 26:883-902, 1981

8.   Tsui BMW, Metz CE, and Beck RN.  Optimum Detector Spatial Resolution for Discriminating Between Tumor Uptake Distributions in Scintigraphy.  Phys Med Biol 28(7): 775-788, 1983.

9.   Tsui BMW, Jaszczak RJ.  Interactions of Collimation, Sampling and Filtering on SPECT Spatial Resolution.  IEEE on Nucl Sci NS-31 (1): 527-532, 1984

10.  Gullberg GT, Crawford CR, and Tsui BMW.  Reconstruction Algorithm for Fan Beam with a Displayed Center-of-Rotation.  IEEE Trans in Med Imaging MI-5: 23-29, 1986

11.  Tsui BMW, Gullberg GT, Edgerton ER, Gilland DR, Perry JR, and McCartney WH.  The Design and Clinical Utility of a Fan Beam Collimator for a SPECT System.  J Nucl Med 27:810-819, 1986

12. Chang W, Tsui BMW, Tian C, Li S, Williams JJ, Rezai K, Ehrhardt JC, and Kirchner PT.  Design and Investigation of a Four-Quadrant Multiple Detector Ring System for Single Photon Emission Computed Tomography (SPECT).  SPIE 671:200-205, 1986

13.  Saloner D, Moran PR, and Tsui BMW.  Velocity Imaging by Rapid Cycle Tagging.  Med Phys 14(2):167-171, 1987

14.  Moran PR, Saloner D, and Tsui BMW.  NMR Velocity-Selective Excitation Composites for Flow and Motion Imaging and Suppression of Static Tissue Signals.  IEEE Trans on Med Imag Vol. MI-6(2):141-147, 1987

15.  Gullberg GT, Tsui BMW, Crawford CR, and Edgerton ER.  Estimation of Geometric Parameters in Fan Beam Tomography.  Phys Med Biol 32(12): 1581-1594, 1987

16.  Crawford CR, Gullberg GT, and Tsui BMW.  Reconstruction for Fan Beam with an Angular-Dependent Displaced Center-of-Rotation.  Med Phys 15(1): 67-71, 1988

17.  Saloner D, Hinson WH, Moran PR, and Tsui BMW.  MR Flow Imaging in Projection through a Stationary Surround.  J Comp Ass Tomogr 12(1): 122-129, 1988

18.  Tsui BMW, Hu HB, Gilland DR, and Gullberg GT.  Implementation of Simultaneous Attenuation and Detector Response Correction in SPECT.  IEEE Trans Nucl Sci, Vol NS-35 (1): 778-783, 1988

19.  Gilland DR+, Tsui BMW, Perry JR, McCartney WH, and Berg J.  Optimum Filter Function for SPECT Imaging.  J Nucl Med, 29:643-650, 1988

20.  Tsui BMW, Edgerton ER, Gullberg GT, Gilland DR, Perry JR, McCartney WH, and Berg J.  Correction of Nonuniform Attenuation in Cardiac SPECT Imaging Using Iterative Reconstruction Algorithms.  J Nucl Med 30:497-507, 1989 

21.  Gullberg GT, Zeng GL, Tsui BMW and Hagius JT.  An Iterative Reconstruction Algorithm for Single Photon Emission Computed Tomography with Cone Beam Geometry.  Int J of Imag Sys and Techn, Vol. 1, 169-186, 1989

22.  Lathrop KA, Tsui BMW, Chen C-T and Harper PV.  Multiparameter extrapolation of biodistribution data between species.  Health Physics, Vol. 57, Sup. 1, pp 121-126, 1989

23.  Koral KF, Swailem FM, Buchbinder S, Clinthorne NH, Rogers WL and Tsui BMW.  SPECT dual-energy-window Compton correction: Scatter multiplier required for tumor quantification.  J Nucl Med, 31:90-98, 1990

24.  Tsui BMW and Gullberg GT.  The geometric transfer function for cone and fan beam collimators.  Phys Med Biol 35(1): 81-93, 1990

25.  Frey EC* and Tsui BMW. Parameterization of Scatter Response Function in SPECT Imaging Using Monte Carlo Simulation.  IEEE Trans Nucl Sci, NS-37(3):1308-1315, 1990

26.  Gullberg GT, Tsui BMW, Crawford CR, Ballard JG and Hagius JT.  Estimation of Geometrical Parameters and Collimator Evaluation for Cone Beam Tomography.  Med Phys, 17(2): 264-272, 1990

27.  Frey EC* and Tsui BMW.  Spatial properties of the scatter response function in SPECT.  IEEE Trans Nucl Sci, NS-38 (2): 789-794, 1991

28.  Zeng GL, Gullberg GT, Terry JA and Tsui BMW.  Three-dimensional iterative reconstruction algorithms with attenuation and geometric point response correction.  IEEE Trans Nucl Sci, NS-38 (2): 693-702, 1991

29.  Tsui BMW, Zhao XD*, Frey EC and Gullberg GT.  Comparison between ML-EM and WLS-CG Algorithms for SPECT image reconstruction.  IEEE Trans Nucl Sci, NS-38 (6): 1766-1772, 1991

30.  Gilland DR+, Tsui BMW, Metz CE, Jaszczak RJ and Perry JR.  An evaluation of maximum likelihood-EM reconstruction for SPECT by ROC analysis. J Nucl Med, 33:451-457, 1992

31. Lalush DS* and Tsui BMW.  Simulation evaluation of Gibbs prior distributions for use in maximum a posteriori SPECT reconstructions. IEEE Trans Med Imag, 11(2): 267-275, 1992

32.  Cao ZJ* and Tsui BMW.  Performance characteristics of transmission imaging using sheet source with parallel-hole collimation.  Med Phys, 19(5): 1205-1212, 1992

33.  Frey EC*, Tsui BMW and Perry JR.  Simultaneous acqusition of emission and transmission data for improved Tl-201 cardiac SPECT imaging using a Tc-99m transmission source.  J Nucl Med, 33(12): 2238-2245, 1992

34.  Lalush DS* and Tsui BMW.  Attenuation and detector response compensations used with Gibbs prior distributions for maximum a posteriori SPECT reconstruction.  IEEE Trans Nucl Sci, 39:1454-1459, 1992.

35.  Li J, Jaszczak RJ, Greer KL, Coleman RE, Cao ZJ and Tsui BMW.  Direct cone beam SPECT reconstruction with camera tilt.  Phys Med Biol, 38:241-258, 1993

36.  Tsui BMW, Zhao XD*, Cao ZJ and Frey EC.  Reconstruction methods for quantitative brain SPECT.  IEEE Trans Nucl Sci, Vol 40(2): 214-220, 1993

37.  Lalush DS* and Tsui BMW.  A generalized Gibbs prior for maximum a posteriori reconstruction in SPECT.  Phys Med Biol 38: 729-741, 1993 

38.  Cao ZJ* and Tsui BMW.  A fully three-dimensional reconstruction algorithm with non-stationary filter for improved single-orbit cone beam SPECT.  IEEE Trans Nucl Sci, NS-40 (3): 280-287, 1993

39.  Frey EC and Tsui BMW. A practical method for incorporating scatter in a projector-backprojector for accurate scatter compensation in SPECT.  IEEE Trans Nucl Sci, NS-40 (4): 1107-1116, 1993

40.  Cao ZJ* and Tsui BMW.  Improved image quality for asymmetric double-focal cone-beam SPECT.  IEEE Trans Nucl Sci, NS-40 (4): 1145-1148, 1993

41.  Frey EC, ZW Ju and Tsui BMW.  A fast projector-backprojector pair modeling the asymmetric, spatially varying scatter response function for scatter compensation in SPECT imaging.   IEEE Trans Nucl Sci, NS-40 (4): 1192-1197, 1993

42.  Wilson DW+ and Tsui BMW.  Noise properties of filtered-backprojectin and ML-EM reconstructed emission tomographic images.  IEEE Trans Nucl Sci, NS-40 (4): 1198-1203, 1993

43.  Hasegawa BH, Lang TF, Brown JK, Gingold EL, Reily SM, Blankespoor SC, Liew SC, Tsui BMW and Ramanathan C.  Object-specific attenuation correction of SPECT with correlated dual-energy X-ray CT. IEEE Trans Nucl Sci, NS-40 (4): 1242-1252, 1993

44.  Tsui BMW, Terry JA+ and Gullberg GT.  Evaluation of cardiac cone-beam SPECT using observer performance experiments and ROC analysis. Invest Radiol, 28(12): 1101-1112, 1993

45.  Tsui BMW, Zhao XD*, Frey EC and McCartney WH.  Quantitative SPECT: Basics and Clinical Considerations.  Seminar in Nuclear Medicine, Vol XXIV, No 1 (January), pp 38-65, 1994

46.  Tsui BMW, Zhao XD*.  Practical iterative reconstruction methods for quantitative cardiac SPECT image reconstruction. IEEE Trans Nucl Sci, 40(1): 325:330, 1994

47.  Tsui BMW, Frey EC, Zhao XD*, Lalush DS*, Johnston RE and McCartney WH.  The importance and implementation of accurate three-dimensional compensation methods for quantitative SPECT. Phys Med Biol, 39(3): 509-530, 1994

48.  Barrett HH, Wilson DW+ and Tsui BMW.  Noise properties of the EM algorithm: I. Theory. Phys Med Biol, 39(5): 833-846, 1994

49.  Wilson DW+, Barrett HH and Tsui BMW.  Noise properties of the EM algorithm: II. Monte Carlo Simulations. Phys Med Biol, 39(5): 847-871, 1994

50.  Lalush DS* and Tsui BMW.  Improving the convergence of iterative filtered backprojection algorithms. Med Phys, 21(8): 1283-1286, 1994

51.  Cao ZJ and Tsui BMW.  A filtering technique to compensate for detector response in converging-beam SPECT reconstruction.  Phys Med Biol, 39:1281-1293, 1994

52.  Beekman FJ, Frey EC, Kamphuis C, Tsui BMW and Viergever MA.  A new phantom for fast determination of the scatter response of a gamma camera. IEEE Trans Nucl Sci, 41(4): 1481-1488, 1994  

53.  Frey EC and Tsui BMW.  Modeling the scatter response function in inhomogeneous scattering media for SPECT. IEEE Trans Nucl Sci, 41(4): 1585-1593, 1994

54.  Cao ZJ, Frey EC and Tsui BMW.  A scatter model for parallel and converging beam SPECT based on the Klein-Nishina formula. IEEE Trans Nucl Sci, 41(4): 1594-1600, 1994

55.  LaCroix KJ+, Tsui BMW, Hasegawa BH and Brown JK.  Investigation of the use of x-ray CT images for attenuation compensation in SPECT. IEEE Trans Nucl Sci, 41(6): 2793-2799, 1994

56.  Zhao XD*, Tsui BMW, Gregoriou GK*, Li J+, Lalush DS* and Eisner RL.  Evaluation of corrective reconstruction methods using a 3D cardiac-torso phantom and bulls-eye's plots. IEEE Trans Nucl Sci, 41(6): 2831-2837, 1994

57.  Tsui BMW, Zhao XD*, Gregoriou GK*, Lalush DS*, Frey EC, Johnson RE and McCartney.  Quantitative cardiac SPECT reconstruction with reduced image degradation due to patient anatomy. IEEE Trans Nucl Sci, 41(6): 2838-2844, 1994

58.  Lalush DS and Tsui BMW. A fast and stable maximum a posteriori conjuate gradient reconstruction algorithm. Med. Phys. 22(8): 1273-1284, 1995

59.  Frey EC and Tsui BMW. A comparison of Gd-153 and Co-57 as tranmission sources for simultaneous TCT and Tl-201 SPECT. IEEE Trans Nucl Sci, 42(4): 1201-1206, 1995

60.  Li J+, Tsui BMW, Welch A, Frey EC and Gullberg GT. Energy window optimization in simultaneous Technetium-99m TCT and Thallium-201 SPECT data acquisition. IEEE Trans Nucl Sci, 42(4): 1207-1213, 1995

61.  Gregoriou GK*, Tsui BMW and Gullberg GT. Evaluation of the effect of reconstructed image pixel size on defect detectability in Tl-201 fan-beam SPECT by an observer performance study IEEE Trans Nucl Sci, 42(4): 1267-1275, and 1995

62.  LaCroix KJ+, Tsui BMW and Hasegawa BH. Comparison of 180^o and 360^o iterative reconstruction with non-uniform attenuation compensation for SPECT. IEEE Trans Nucl Sci, 42(4): 1276-1281, 1995

63.  DiBella EVR, Eisner RL, Schmarkey LS, Barclay AB, Patterson RE, Nowak DJ, Lalush DS and Tsui BMW. Heterogeneity of SPECT bull’s-eyes in normal dogs: Comparison of attenuation compensation algorithms. IEEE Trans Nucl Sci, 42(4): 1290-1296, 1995

64.  Ju Z-W, Frey EC and Tsui BMW. Fast distributed 3-D iterative reconstruction for quantitative SPECT. IEEE Trans Nucl Sci, 42(4): 1301-1309, 1995

65.  King MA, Tsui BMW and Pan T-S.  Attenuation compensation for cardiac SPECT imaging: Part 1. Impact of attenuation and methods of estimating attenuation maps. J Nucl Cardiol, 2(6): 513-524, 1995

66.  Tsui BMW. Physics of SPECT. RadioGraphics 16:173-183, 1996

67.  King MA, Tsui BMW, Pan T-S, Glick SJ and Soares EJ. Attenuation compensation for cardiac SPECT imaging: Part 2. Attenuation compensation algorithms. J Nucl Cardiol, 3(1): 55-63, 1996

68.  King MA, Xia W, deVries DJ, Pan T-S, Villegas BJ, Dahlberg S, Tsui BMW, Ljungberg MH and Morgan HT.  A Monte Carlo Investigation of artifacts caused by liver uptake in SPECT perfursion imaging with Tc-99m labelled agents. J Nucl Cardiol, 3(1): 18-29, 1996

69. Kadrmas DJ, Frey EC and Tsui, BMW.  An SVD investigation of modeling scatter in multiple energy windows for improved SPECT images. IEEE Trans Nucl Sci, 43(4): 2275-2284, 1996

70. Pan T-S, Tsui BMW and Byrne CL.  Choice of initial conditions in the ML reconstruction of fan-beam transmission with truncated projection data.  IEEE Trans Med Imag, 16(4): 426-438, 1997

71. Pretorius PH, Xia W. King MA, Tsui BMW, Pan T-S and Villegas BJ. Evaluation of right and left ventricular volume and ejection fraction using a mathematical cardiac torso phantom for gated blood pool SPECT. J Nucl Med, 38:1528-1535, 1997

72. De Vries DJ, King MA, Soares EJ, Tsui BMW and Metz CE.  Evaluation of the effect of scatter correction on lesion detection in hepatic SPECT imaging.  IEEE Trans Nucl Sci, 44(5): 1733-1740, 1997

73. Kadrmas DJ, Frey EC and Tsui BMW.  Analysis of the reconstructibility and noise properties of scattered photons in Tc-99m SPECT. Phys Med Biol, 42:2493-2516, 1997

74. Gregoriou GK*, Tsui BMW and Gullberg GT.  Effect of truncated projections on defect detection in attenuation compensation fan-beam cardiac SPECT.  J Nucl Med, 39:166-175, 1998

75. LaCroix KJ+, Tsui BMW and Hasegawa BH. A comparison of 180^o and 360^o acquisition for attenuation compensated Tl-201 images acquired on multi-detector SPECT systems.  J Nucl Med, 39:562-574, 1998

76. Frey EC, Tsui BMW and Gullberg GT.  Improved estimation of the detector response function for converging beam collimators.  Phys Med Biol, 43:941-950, 1998

77. Kadrmas DJ, Frey EC, Karimi SS and Tsui BMW.  Fast implementations of reconstruction-based scatter scompensation in fully 3D SPECT image reconstruction. Phys Med Biol, 43: 857-874, 1998

78. Lalush DS and Tsui BMW. Block-iterative techniques for fast 4D reconstruction using a priori motion models in gated cardiac SPECT. Phys Med Biol, 43:875-887, 1998

79. Achtert A-D, King MA, Dahlberg ST, Pretorius, PH, LaCroix KJ and Tsui, BMW. An investigation of the estimation of EF and cardiac volumes by a quantitative gated SPECT software package in simulated gated SPECT perfusion images. J Nucl Cardiol, 5(2):144-152, 1998

80. Lalush DS and Tsui BMW.  Mean-Variance Analysis of Block-Iterative Reconstruction Algorithms Modeling 3D Detector Response in SPECT. IEEE TNS, 45(3): 1280-1287, 1998

81. Jang S, Jaszczak RJ, Tsui BMW, Metz CE, Gilland DR, Turkington TG and Colemen RE.  ROC evaluation of SPECT myocardial lesion detectability with and without single iteration non-uniform Chang attenuation compensation using an anthropomorphic female phantom. IEEE Trans Nucl Sci, 45(4): 2080-2088, 1998

82. Tsui BMW, Wessell DE+, Zhao, XD, Wang WT, Lewis DP and Frey EC. Imaging characteristics of scintimammography using parallel-hole and pinhole collimators. IEEE Trans Nucl Sci, 45(4): 2155-2161, 1998

83. Kadrmas DJ, Frey EC and Tsui BMW.  Application of reconstruction-based scatter compensation to Tl-201 SPECT: Implementations for reduced reconstructed image noise. IEEE Trans Med Imaging, 17(3): 325-333,1998

84. Tsui BMW, Frey EC, LaCroix KJ+, Lalush DS, McCartney WH, King MA and Gullberg GT. Quantitative Myocardial Perfusion SPECT. J Nucl Cardiol, 5(5): 507-522, 1998

85. Lewis DP+ Tsui BMW and Moran PR. Velocity Sensitivity of Slice Selective Excitation. Mag. Res. Imag, 16(8): 907-916, 1998

86. Wollenweber SD*, Tsui BMW, Lalush DS, Frey EC and Gullberg GT.  Evaluation of Myocardial Defect Detection Between Parallel-hole and Fan-beam SPECT Using the Hotelling Trace, IEEE Trans Nucl Sci, 45(4):  2205-2210, 1998.

87. Segars WP+, Lalush DS and Tsui BMW. A realistic spline-based dynamic heart phantom. IEEE Trans Nucl Sci, 46(3):503-506, 1999.

88. Kadrmas DJ, Frey EC and Tsui BMW. Simultaneous Technetium99m/Thallium-201 SPECT imaging with model-based compensation for cross-contamination effects. Phys Med Biol, 44:1843-1860, 1999.

89.   Pretorius PH, King MA, Tsui BMW, LaCroix KJ* and Xia W. A mathematical model of motion of the heart for use in generating source and attenuation maps for simulating emission imaging. Med Phys, 26(11): 2323-2332, 1999.

90.   de Vries DJ, King MA, Soares EJ, Tsui BMW and Metz CE. Effects of scatter subtraction on detection and quantitation in hepatic SPECT, J Nucl Med, 40:1011-1023, 1999.

91.   LaCroix KJ*, Tsui BMW, Frey EC and Jaszczak RJ. An ROC evaluation of iterative reconstruction with attenuation compensation in Tc-99m-Sestamibi myocardial SPECT images. J Nucl Med 41(3): 502-513, 2000.

92.   LaCroix KJ* and Tsui BMW. Investigation of 90^o Dual-Camera Half-Fanbeam Collimation for Myocardial SPECT Imaging.  IEEE Trans Nucl Sci, 46(6): 2085-2092, 1999.

93.   Lalush DS, Tsui BMW.  Performance of Ordered-Subset Reconstruction Algorithms under Conditions of Extreme Attenuation and Truncation in Myocardial SPECT.  J Nucl Med 2000, 41(4):  737-744.

94.   Lalush DS, Frey EC and Tsui BMW. Fast Maximum Entropy Approximation in SPECT Using the RBI-MAP Algorithm.  IEEE Trans. Med. Imaging, 19(4): 286-294, 2000.

95.   DS Lalush and Tsui BMW. Fast Transmission CT Reconstruction for SPECT Using a Block-Iterative Algorithm. IEEE Trans Nucl Sci, 47(3): 1123-1129, 2000.

96.   Tsui BMW, Segars WP⁺, Lalush DS. Effects of Upward Creep and Respiratory Motions in Myocardial SPECT. IEEE Trans Nucl Sci, 47(3): 1192-1195, 2000.

97.   Segars WP⁺, Lalush DS, Tsui BMW. Modeling Respiratory Mechanics in the MCAT and Spline-Based MCAT Phantoms. IEEE Trans Nucl Sci, 48(1):  89-97, 2001.

98.   MacDonald LR, Patt BE, Iwanczyk JS, Tsui BMW, Wang Y, Frey EC, Wessell DE, Acton PD and Kung HF.  Pinhole SPECT of Mice Using the LumaGEM Gamma Camera.  IEEE Trans Nucl Sci, 48(3):  830-836, 2001.

99.   Tocharoenchai C, Tsui BMW and Frey EC. Performance characterization of a Siemens E.CAM+ Hybrid PET System. Thai Nuclear Medicine Journal, 1:51-60, 2002.

100.   Tocharoenchai, Tsui BMW and Frey EC. Factor affecting spatial resolution of a hybrid PET system. Thai Nuclear Medicine Journal, 1:74-80, 2002.

101.   Sankaran S, Frey, EC, Gilland KL and Tsui BMW. Determination of Optimum Compensation Method Combination and Filter Cutoff Choice in Myocardial SPECT:  A Human Observer Study, J Nucl Med., 43: 432-438, 2002.

102.   Du Y, Frey EC, Wang WT, Tocharoenchai C, Baird WH and Tsui BMW. Combination of MCNP and SimSET for Monte Carlo Simulation of SPECT with Medium and High Energy Photons, IEEE Trans. Nucl. Sci., 49(3): 668-674, 2002.

103.   Segars WP* and Tsui BMW. Study of the Efficacy of Respiratory Gating in Myocardial SPECT Using the New 4D NCAT Phantom. IEEE TNS Nucl Sci, Vol. 49(3): 675-679, 2002.

104.   Tsui, BMW.  Interpreting Results from a Comparative Study of Lesion Detectability for 6 Different PET Systems, J Nucl Med, 43(11): 1555-1556, 2002.

105.   Frey EC, Gilland KL* and Tsui BMW.  Application of task-based measures of image quality to optimization and evaluation of three-dimensional reconstruction-based compensation methods in myocardial perfusion SPECT.  IEEE Transactions on Medical Imaging, 21(9):1040-1050, 2002.

106.   Wang WT, Frey EC, Tsui BMW, Tocharoenchai C and Baird WH. Parameterization of Pb X-Ray Contamination in Simultaneous Tl-201 and Tc-99m Dual-Isotope Imaging, IEEE TNS, 49(3):  680-692, 2002.

107.   Baird WH, Frey EC, Tsui BMW, Wang YC⁺, and Wessell DE. Evaluation of Rotating Slant-Hole SPECT Mammography Using Monte-Carlo Simulation Methods, IEEE TNS 50(1):  105-109, 2003.

108.   Garrity JM⁺, Segars WP, Knisley SB and Tsui BMW.  Development of a Dynamic Model for the Lung Lobes and Airway Tree in the NCAT Phantom.  IEEE TNS, 50(3):  378-383, 2003.

109.   Du Y, Frey EC, Wang WT and Tsui BMW.  Optimization of Acquisition Energy Windows in Simultaneous Tc-99m/I-123 Brain SPECT.  IEEE TNS 50(5):  1556-1561, 2003.

110.   Song X, Frey EC, Wang WT, Du Y and Tsui BMW.  Validation and Evaluation of Model-Based Crosstalk Compensation Method in Simultaneous Tc-99m Stress and Tl-201 Rest Myocardial Perfusion SPECT.  IEEE TNS 51(1):  72-79, 2004.

111.   He X, Frey EC, Links JM, Gilland KL, Segars WP and Tsui BMW.  A Mathematical Observer Study for the Evaluation and Optimization of Compensation Methods for Myocardial SPECT Using a Phantom Population That Realistically Models Patient Variablility.  IEEE TNS 51(1):  218-224, 2004.

112.   Segars WP, Tsui BMW, Frey EC, Johnson GA and Berr SS.  Development of a 4-D digital mouse phantom for molecular imaging research. Molecular Imaging & Biology, Volume 6, Issue 3, May-June 2004, Pages 149-159.

113.   Qi Y*, Tsui BMW, Gilland KJ, Frey EC, and Gullberg GT. Evaluation of Parallel and Fan-Beam Data Acquisition Geometries and Strategies for Myocardial SPECT Imaging, IEEE TNS 51(4): 667-672, 2004.

114.   Pani R, Pellegrini, R, Cinti MN,  Trotta C,  Bennati P,  Betti M, De Vincentis G,  Cusanno F,  Garibaldi F,  Ridolfi S,  Majewski S and  Tsui BMW. New Devices for Imaging in Nuclear Medicine, Cancer Biotherapy & Radiopharmaceuticals, 19(1), 121-128, 2004.

115.   Tocharoenchai C, Tsui BMW, Frey EC, Wang WT, “Effect of Attenuation Correction on Lesion Detection using a Hybrid PET System”, Journal of the Medical Association of Thailand, 88(1): pp96-102, 2005.

116.   Song X, Segars WP, Du Y, Tsui BMW and Frey EC. Fast modeling of the collimator-detector response in Mone Carlo simulation of SPECT imaging using the angular response function, Phys Med Biol 50: 1791-1804, 2005.

117.   Tsui BMW and Wang Y. High-Resolution Molecular Imaging Techniques for Cardiovascular Research. J Nucl Cardiol 12:262-267, 2005.

118.   Kraitchman DL, Tatsumi M, Gilson WD, Ishimori T, Kedziorek D, Walczak P, Segars WP, Chen HH, Fritzges D, Izbudak I, Young RG, Marcelino M, Pittenger MF, Solaiyappan M, Boston RC, Tsui BMW, Wahl RL and  Bulte JWM. Dynamic Imaging of Allogeneic Mesenchymal Stem Cells Trafficking to Myocardial Infarction. Circulation 112:1454-1464, 2005.

119.   Du Y, Tsui BMW and Frey EC. Partial volume effect compensation for quantitative brain SPECT imaging, IEEE Trans Med Imag, 2005, in press.

120.   Wang WT, Frey EC, Tsui BMW, Lalush DS, and Tocharoenchai C. Optimization of acquisition parameters for simultaneous ²⁰¹Tl and ^99mTc dual-isotope myocardial imaging, IEEE Trans Nucl Sci, 2005 in press.

121.   He X, Links JM, Song X, Tsui BMW, and Frey EC. Comparison of penetration and scatter effects on detect contract for GE and siemens LEHR collimators in myocardial perfusion SPECT – A simulation study. IEEE Trans Nucl  Sci, 2005, in press.

122.   Stumpf MJ, Frey EC, Tsui BMW and Gullberg GT. An investigation of noise characteristics in OSEM reconstruction of fan beam SPECT using a rotating/Warping Projector/Backprojector. submitted to IEEE Trans Nucl Sci, November 2005.

123.   He X, Links JM, Tsui BMW and Frey EC. Comparison of 180-degree and 360-degreeacquisition for myocardial perfusion SPECT with compensation for attenuation, detector response, and scatter: Monte Carlo and mathematical observer results. Journal of Nuclear Medicine, submitted.

124.   Veress AI, Segars WP, Tsui BMW, Weiss JA and Gullberg GT. Normal and Pathological NCAT Image and Phantom Data Based on Physiologically Realistic Left Ventricle Finite Element Models. Manuscript accepted for publication in IEEE Transactions in Med Imaging, 2005.

125.   Wang YC and Tsui BMW. Application of Homogeneous Coordinates in the Development and Implementation of Iterative Reconstruction Algorithms for Pinhole SPECT with Different Data Acquisition Geometries.  Manuscript submitted to IEEE Transactions in Medical Imaging, 2005.

126.   Xu J,  Liu C,  Wang Y,  Frey EC  and  Tsui BMW. Quantitative Rotating Multi-Segment Slant-Hole SPECT Mammography with Attenuation and Collimator-Detector Response Compensation.  Manuscript submitted to IEEE Transactions in Medical Imaging, 2005.

127.   Lee T-S, Segars WP and Tsui BMW. Development and Optimization of a 4D MAP-RBI-EM Reconstruction Algorithm with Space-Time Gibbs Priors for Application to Gated Myocardial Perfusion SPECT.  Manuscript submitted to IEEE Transactions in Medical Imaging, 2005.

128.   Xu J, Wang Y, Liu C, Frey EC and Tsui BMW. Attenuation correction for rotating multisegment slant-hole SPECT in breast imaging,” submitted to Physica Medica.

129.   Segars W, Silva AD, Shao L and Tsui B. CT-PET image fusion using the 4D NCAT phantom with the purpose of attenuation correction. Accepted for publcation, IEEE TNS, 2006.

________________________________________________________________________

+ Graduate student under direct supervision

* Postdoctoral Fellow/Research Associate under direct supervision

B.  Non-peer reviewed Articles

*** The following 2 manuscripts are in: Proceedings of the Third International Radiopharmaceutical Dosimetry Symposium, Oak Ridge, Tennessee, and October 7-10, 1980. HHS Publication FDA 81-8166, 1981.

1.   Tsui BMW, Chen C-T, Yasillo NJ, Ortega CJ, Charleston DB, Harper PV, and Lathrop KA.  Description of the Design and Use of a Whole-Body Scanning System for Collection of Quantitative in Vivo Distribution Data in Humans. pp. 138-156, 1981.

2.   Tsui BMW, Lathrop KA, and Harper PV.  Extrapolation of Tissue Distribution Data for *T1 and *Ga from Animal to Human. pp. 283-291, 1981.

3.   Jaszczak RJ, Greer KL, Coleman, RE and Tsui BMW.  SPECT Instrumentation: Evaluation of System Performance.  In Proceedings of Southeastern Chapter of Society of Nuclear Medicine - Continuing Education Lectures, Simon GH, ed., (Society of Nuclear Medicine, NY), Chapter VIII: 1-14, 1985.

4.   Crawford CR, Gullberg GT, and Tsui BMW.  Fan Beam Reconstruction for Displayed Center-of-Rotation.  In Proceedings of the Seventh Annual Conference of the Engineering in Medicine and Biology Society, IEEE 930-933, 1985.

*** The following 2 manuscripts are in: Proceedings of the 11th Annual University of North Carolina Radiology Symposium, 1987.

5.   Tsui BMW.  Recent Advances in SPECT Imaging. pp. 30-39, 1987.

6.   Tsui BMW.  Current Status of MRI Imaging. pp. 69-76, 1987.

7.   Tsui BMW.  Recent Advances in SPECT Instrumentation and Image Processing Techniques.  In Proceedings of Southeastern Chapter of Society of Nuclear Medicine - Continuing Education Lectures, E.B. Silberstein, ed.  (Society of Nuclear Medicine, NY), pp. XX-1-XX-10, 1987.

8.   DiBianca FA, Vance JE, Wagenaar DJ, Fetter JE, Tenney CR, Tsui BMW, Reed MS, McDaniel DL, and Granfors P.  Noise Properties of a Kinestic Charge Detector.  In Proceedings of Society of Photo-Optical Instrumentation Engineering, 914:212-218, 1988.

9.   Tsui BMW, Perry JR, Gilland DR, Interrante VL, Pizer SM, Fuchs H, and McCartney WH.  Simultaneous Three-Dimensional Display of Anatomical and Functional Information Obtained With SPECT.  In Imaging Hardware and Software for Nuclear Medicine, RE Zimmerman and JM Links eds., AAPM Symposium Proceedings No. 6, (AIP, New York) pp. 197-206, 1988.

10.  Gullberg GT and Tsui, BMW.  Maximum Entropy Reconstruction With Constraints:  Iterative Algorithms for Solving the Primal and Dual Program.  In Proceedings of the Tenth International Conference on Information Processing in Medical Image, June 22-26 1987, Utrecht, The Netherlands, (Plenum, New York) pp. 181-199, 1988.

11.  Tsui BMW, Zhao XD, Frey EC, Perry JR and Gullberg GT.  Acquisition and image reconstruction methods for improved cardiac SPECT imaging.  In: Biomedical Engineering: Opening New Doors. (Proceedings of the 1990 Fall Meeting of the Biomedical Engineering Society, Blacksburg, VA, 1990), New York University Press, pp 221-229, 1990.

*** The following 2 manuscripts are in: Biomedical Engineering: Opening New Doors. (Proceedings of the 1990 Fall Meeting of the Biomedical Engineering Society, Blacksburg, VA, 1990), New York University Press, 1990.

12.  Terry JA+, Tsui BMW, Perry JR, Hendricks JL and Gullberg GT.  The design of a mathematical phantom of the upper human torso for use in 3-D SPECT imaging research, pp 185-190, 1990.

13.  Ballard JG+, Tsui BMW and Johnston RE.  Quantitative evaluation of two SPECT reconstruction techniques. pp 147-154, 1990.

14.  Gullberg GT, Zeng GL, Christian PE, Tsui BMW and Morgan HT.  Single Photon Emission Computed Tomography of the Heart Using Cone Beam Geometry and Noncircular Detector Rotation. In Information Processing in Medical Imaging, XIth Information Processing in Medical Imaging (IPMI) International Conference, Berkeley, CA, June 19-23, Eds Ortendahl DA and Llacer J, Wiley-Liss, New York, pp 123-138, 1991.

*** The following 5 manuscripts are in: Conference Record of the 1990 Nuclear Science Symposium and the Medical Imaging Conference 90, October 23-27, Arlington, VA, 1990.

15.  Tsui BMW, Zhao XD, Frey EC and Gullberg GT.  Properties of Iterative algorithms in SPECT image reconstruction. pp. 1467-1474, 1990.

16.  Frey EC* and Tsui BMW.  Spatial properties of the scatter response function in SPECT. pp. 1183-1188, 1990.

17.  Lalush DS+ and Tsui BMW.  Simulation evaluation of Gibbs prior distributions for use in maximum a posteriori SPECT reconstructions. pp. 1600-1609, 1990.

18.  Zeng GL, Gullberg GT, Terry JA and Tsui BMW.  Three-dimensional iterative reconstruction algorithms with attenuation and geometric point response correction. pp. 1475-1479, 1990.

19.  Reilly SM, Hasegawa BH, Gingold EL, Ramanathan C and Tsui BMW.  A computer simulation of simultaneous emission - transmission CT. pp. 1212, 1990.

*** The following 5 manuscripts are in: Conference Record of the 1991 Nuclear Science Symposium and the Medical Imaging Conference, November 2-9, Santa Fe, NM, 1991.

20.  Tsui BMW, Zhao XD, Cao ZJ* and Frey EC*.  Reconstruction methods for quantitative brain SPECT. pp. 1763-1769, 1991.

21.  Frey EC* and Tsui BMW.  A practical-backprojector modeling attenuation, detector response, and scatter for accurate scatter compensation in SPECT. pp. 1777-1781, 1991. 

22.  Cao ZJ* and Tsui BMW.  Non-stationary filtering technique for improved cone beam SPECT. pp. 1938-1942, 1991.

23.  Wilson DW+, Tsui BMW and Terry JA+.  Non-stationary noise characteristics for SPECT images. pp. 1736-1740, 1991.

24.  Lalush DS+ and Tsui BMW.  Attenuation and detector response compensations used with Gibbs prior distributions for maximum a posteriori SPECT reconstruction. pp 1797-1802, 1991.

*** The following 2 manuscripts are in: Proceedings of the NATO Advanced Study Institute on the Formation, Handling, and Evaluation of Medical Image, September 12-23, 1988, Porto, Portugal, A.E. Todd-Pokropek and M.A. Viergever eds., NATO ASI Series, F, Springer-Verlag, Heidelberg, 1992

25. Tsui BMW, Hu HB, Gullberg, GT, Gilland DR, Ballard JG, Perry JR, McCartney WH, and Bernstein T.  Applications of Iterative Reconstruction Methods in SPECT.  pp 503-524, 1992.

26.  Gilland DR+, Tsui BMW, Hu HB, and Perry JR.  Computed Simulated Cardiac SPECT Data for Use in Evaluating Reconstruction Algorithms. pp 525-538, 1992.

*** The following 7 manuscripts are in: Conference Record of the 1992 Nuclear Science Symposium and the Medical Imaging Conference, October 27-31, Orlando, FL, 1992.

27.  Lalush DS* and Tsui BMW.  Optimization of Gibbs Priors based on Object Size and Contrast for Maximum A Posteriori Reconstruction in SPECT. pp 1023-1025, 1993.

28.  Frey EC, Ju ZW and Tsui BMW.  A fast projector-backprojector pair modeling the asymmetric, spatially compensation in SPECT imaging. pp 1032-1034, 1993.

29.  Frey EC and Tsui BMW.  A comparison of scatter compensation methods in SPECT: Subtraction-based Techniques versus iterative reconstruction with an accurate scatter model. pp 1035-1037, 1993.

30.  Cao ZJ* and Tsui BMW.  Improved image quality for asymmetric double-focal cone beam SPECT. pp 1068-1070, 1993.

31.  Cao ZJ* and Tsui BMW.  A practical reconstruction algorithm for multifocal cone beam SPECT. pp 1074-1076, 1993.

32. Wilson DW+ and Tsui BMW.  Noise properties of filtered-backprojection and ML-EM reconstructed emission tomographic images. pp 1114-1116, 1993.

33.  Tsui BMW, Zhao XD*.  Practical iterative reconstruction methods for quantitative cardiac SPECT image reconstruction. p 1178, 1993.

34.  Zhao XD*, Tsui BMW, Gregoriou GK*, Li J+, Lalush DS* and Eisner RL.  Evaluation of corrective reconstruction methods using a 3D cardiac-torso phantom and bulls-eye's plots. pp 1164-1168, 1994. 

35.  LaCroix KJ+, Tsui BMW, Hasegawa BH and Brown JK.  Investigation of the use of x-ray CT images for Attenuation compensation in SPECT. pp 1169-1173, 1994. 

36.  Lalush DS* and Tsui BMW.  MAP-EM and WLS-MAP-CG reconstruction methods for transmission imaging in cardiac SPECT. pp 1174-1178, 1994. 

37.  Cao ZJ, Frey EC and Tsui BMW.  A scatter model for parallel and converging beam SPECT based on the Klein-Nishina formula. pp 1179-1183, 1994. 

38.  Frey EC and Tsui BMW.  Modeling the scatter response function in inhomogeneous scattering media for SPECT. pp 1184-1188, 1994. 

39.  Wilson DW+ and Tsui BMW.  Spatial resolution properties of FB and ML-EM reconstruction methods. pp 1189-1193, 1994. 

40. Tsui BMW, Zhao XD*, Gregoriou GK*, Lalush DS*, Frey EC, Johnson RE and McCartney.  Quantitative  cardiac SPECT reconstruction with reduced image degradation due to patient anatomy. pp 1444-1448, 1994.

41. Beekman FJ, Frey EC, Kamphuis C, Tsui BMW and Viergever MA.  A new phantom for fast determination of the scatter response of a gamma camera. pp 1847-1851, 1994.

42.  Tsui BMW. Single-photon emission computed tomography (SPECT) imaging.  In Proceedings of the 1994 IEEE International Conference on Image Processing, November 13-16, Austin, TX, 1994, pp 1031-1035, 1994.

*** The following 8 manuscripts are in: Conference Record of the 1994 Nuclear Science Symposium and the Medical Imaging Conference, October 30 - November 5, Norfolk, VA, 1994.

43.  Tsui BMW, Lewis DP+ and Li J+. Detection efficiencies of parallel, fan and cone beam collimators for source distributions in an attenuating medium. pp 1145-1149, 1995.

44.  LaCroix KJ+, Tsui BMW and Hasegawa BH. Comparison of 180^o and 360^o iterative reconstruction with non-uniform attenuation compensation for SPECT. pp 1197-1201, 1995.

45.  Cao Z and Tsui BMW. A novel SPECT collimation system and related reconstruction algoritum. pp 1266-1269, 1995.

46.  Welch A, Gullberg GT, Christian PE, Li J+ and Tsui BMW. An investigation of dual-energy transmission measurements for more accurate non-uniform attenuation compensation in cardiac SPECT. pp 1558-1662, 1995.

47.  Frey EC and Tsui BMW. A comparison of Gd-153 and Co-57 as tranmission sources for simultaneous TCT and Tl-201 SPECT. pp 1582-1586, 1995.

48.  Li J+, Tsui BMW, Welch A, Frey EC and Gullberg GT. Energy window optimization in simultaneous Technetium-99m TCT and Thallium-201 SPECT data acquisition. pp 1587-1594, 1995.

49.  DiBella EVR, Eisner RL, Schmarkey LS, Barclay AB, Patterson RE, Nowak DJ, Lalush DS and Tsui BMW. Heterogeneity of SPECT bull’s-eyes in normal dogs: Comparison of attenuation compensation algorithms. pp 1725-1729, 1995.

50.  Gregoriou GK*, Tsui BMW and Gullberg GT. Evaluation of the effect of reconstructed image pixel size on defect detectability in Tl-201 fan-beam SPECT by an observer performance study. pp 1907-1914, 1995.

*** The following 3 manuscripts are in: Proceedings of the 1995 International Meeting on Fully Three-Dimensional Image Reconstruction in Radiology and Nuclear Medicine, July 4-6, Aix-les-Bains, Savoie, France, 1995.

51.  Tsui BMW, Zhao XD^*, Frey EC, JU Z-W and Gullberg GT. Characteristics of reconstructed point response in three-dimensional spatially variant detector response compensaiton in SPECT. pp 161-168, 1995.

52.  Lalush DS and Tsui BMW. Space-time Gibbs priors applied to gated SPECT myocardial perfusion studies. pp. 37-42, 1995.

53.  Frey EC, Ju Z-W and Tsui BMW. Reducing reconstruction time for iterative 3-D reconstruction scatter compensation. pp. 201-206, 1995.

54.  Tsui BMW. Attenuation Correction in SPECT.  Proceedings of the Southeastern Chapter Meeting of the Society of Nuclear Medicine, October 20-22, 1995, Orlando, FL, p. XIX-1 to XIX-7

*** The following 7 manuscripts are in: Conference Record of the 1995 Nuclear Science Symposium and the Medical Imaging Conference, October 21 - 28, San Francisco, CA, 1995.

55.  Kadrmas DJ, Frey EC and Tsui BMW. An SVD investigation of modeling scatter in multiple energy windows for improved SPECT images. pp 1097-1101.

56.  Tsui BMW, Zhao XD^* and Frey EC.  3D detector response compensation in SPECT using multigrid iteration reconstruction methods. pp. 1151-1155.

57.  Li J⁺, Tsui BMW, Frey EC and Gullberg GT.  Deconvolution scatter compensation for Thallium-201 fan-beam cardiac SPECT. pp 1175-1179.